ACC&D Product Profile and Position Papers
ACC&D is working to build a library of Product Profile and Position Papers (PPPPs) on contraceptive and sterilant technologies which are currently available. Please note that most currently-available approaches do not meet our priorities of being demonstrated to be safe, effective, and permanent in one treatment. However, because these products are available, we often receive questions about them, and we hope the information in these documents will help those who are considering these products make the best decision for the animals in their care. Don't be a stranger to this page, as we'll be adding products to this section routinely.
Zeuterin Product Profile and Position Paper Zeuterin™ (marketed as Esterisol™ in some countries) is a non-surgical sterilant for male dogs delivered via intratesticular injection. The Active ingredient is zinc gluconate neutralized with arginine. The formulation causes permanent sterility in one treatment. The process of neutering with Zeuterin™/ EsteriSol™ is also known as "zinc neutering."
GonaCon™ Formulations Product Profile and Position Paper
GnRH-hemocyanin conjugate immunocontraceptive vaccine formulations have been shown to prevent reproduction in multiple mammalian species for extended periods. GonaCon™ and GonaCon-Equine™ are registered with the U.S. EPA for female white-tailed deer and wild/feral horses and burros, respectively. Studies indicate that a GnRH-hemocyanin conjugate immunocontraceptive vaccine has potential for multi-year contraception among free-roaming/feral cats. Work to develop an effective, safe formulation for free-roaming dogs is ongoing.
Megestrol Acetate Product Profile and Position Paper
Megestrol acetate is used as an oral contraceptive in female dogs and cats. Megestrol acetate is available in a number of countries under different brand names and in some places as a generic. For a period of time in the U.S., a low-dose version of Megestrol acetate was marketed as FeralStat for contraception of feral cats (see below for details). Please note that this PPPP is in the process of being updated to incorporate recent research findings on this oral contraceptive.
FeralStat™ Product Profile and Position Paper
FeralStat™ was an oral contraceptive, consisting of low-dose megestrol acetate, which was prescribed for management of feral cat colony populations by a private veterinarian in the U.S. state of Connecticut. It is no longer on the market. However, the active ingredient, megestrol acetate, can still be purchased in generic and name-brand forms for contraception of cats and dogs; we therefore include this document for those considering using low-dose megestrol acetate. As with our Megestrol Acetate PPPP, please note that this PPPP is in the process of being updated to incorporate recent research findings on this oral contraceptive.