Suprelorin® (deslorelin acetate) for male dogs
Suprelorin® is a subcutaneous implant designed to prevent fertility and suppress libido in male dogs for a minimum of six or twelve months, depending on the size of the implant (4.7 vs. 9.4mg). Developed by Peptech Animal Health, which was later purchased by Virbac Animal Health, Suprelorin is approved for male dog contraception in Australia, New Zealand (4.7mg dose only), and the European Union.
How does Suprelorin work? The implant, placed beneath the skin between the shoulders, releases a slow and continuous dose of deslorelin, a gonadotropin-releasing hormone (GnRH) analog. Deslorelin suppresses the reproductive endocrine system by preventing the production of pituitary hormones and testosterone, the male gonadal hormone.
So long as deslorelin is being released, the dog remains infertile and behaves as if castrated. (Note, however, that the manufacturer reports that it will generally take 2-3 weeks after implantation for testosterone to be reduced, and about 6 weeks to become infertile due to sperm stored in the reproductive tract).
ACC&D believes that Suprelorin offers value for dogs who cannot safely undergo surgery, persons who wish to prevent fertility and testosterone production without castration (dogs can receive sequential implants), and persons who are unsure about castration and want to “trial” a “castrated” dog—for example, persons who want to ensure that castration would not impact their dog’s working, herding, or hunting abilities. Numerous studies have found that the fertility suppression effect of Suprelorin is reversible, even after multiple (up to four) consecutive implants.
Want to learn more about Suprelorin for male dogs? Check out the resources below:
ACC&D Suprelorin Product Profile and Position Paper
Contraception & Fertility Control in Dogs & Cats (ACC&D’s e-book)
Interested in the use of deslorelin for cats and female dogs?
Please visit our Products under Development page.