Gene Silencing Potential for Sterilization of Cats and Dogs
October 15-17, 2009
Use of interfering RNA (RNAi) and other technologies for gene silencing (which essentially involves “turning off” genes) is on the cutting edge of human medicine and shows promise in multiple therapeutic areas, including treatment of cancer, infectious and respiratory diseases, and neurodegenerative disorders. However, research on gene silencing for human medical applications has generally not explored targeting genes involved in reproductive control. This is particularly true when it comes to animals. ACC&D has identified this area as one with both promise and challenges, making it a prime topic for a Think Tank gathering of experts.
Think Tank participants discussed pathways where inhibition of a gene might interfere with reproduction and fertility, including master reproductive hormone, germ cells, pheromone signals, fertilization, embryo implantation, and trophoblast/embryo support. You can learn more about conclusions and recommendations in our Think Tank report and 4th International Symposium presentation.
Thank you to the Found Animals Foundation and the Animal Assistance Foundation for sponsoring this event!